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.45 Automatic Colt Pistol is a somewhat common though arguably obsolete high-powered military caliber once upon a time used in submachine guns though still a moderately common handgun cartridge. In NMRiH, .45 ACP comes in boxes at a minimum of 1 and a maximum of 21 rounds per box. As a cartridge .45 ACP ammunition has medium-to-high damage output and medium range performance.
.45 ACP ammunition is used in the following weapons:
- Colt 1911 National Match - a maximum of 7 rounds per magazine
- MAC-10 - a maximum of 30 rounds per magazine